
How are Crohn’s disease and ulcerative colitis similar? What sets them apart? Crohn’s disease and ulcerative colitis (colitis) are inflammatory bowel diseases characterized by an autoimmune response that damages the mucosa, or inner lining, of your intestine. In ulcerative colitis, inflammation is limited to the colon and rectum, while Crohn’s disease can involve any portion of the gastrointestinal tract, from mouth to anus. The inflammation